MMP14

Gene

matrix metallopeptidase 14

HGNCHGNC:7160 EnsemblENSG00000157227 NCBI Gene4323

Locus: gene with protein productLocation: 14q11.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Matrix metalloproteinase-14P50281

Protein · therapeutic target

Clinical-stage target · 2 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMT1-MMP

View full nomenclature history (5)

Alias symbolsMT1-MMP

Previous namesmatrix metalloproteinase 14 (membrane-inserted), matrix metallopeptidase 14 (membrane-inserted)

Alias namesmembrane type 1 metalloprotease, membrane type 1-matrix metalloproteinase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dupuytren Contracture

Carcinoma, Non-Small-Cell Lung

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

M10 matrix metallopeptidasesElastases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.