MMP2

Gene

matrix metallopeptidase 2

HGNCHGNC:7166 EnsemblENSG00000087245 NCBI Gene4313

Locus: gene with protein productLocation: 16q12.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

72 kDa type IV collagenaseP08253

Protein · therapeutic target

Clinical-stage target · 3 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCLG4 · CLG4A · TBE-1 · MMP-2

View full nomenclature history (5)

Previous symbolsCLG4, CLG4A

Alias symbolsTBE-1, MMP-2

Previous namesmatrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Breast Neoplasms

Musculoskeletal Diseases

Prostatic Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

M10 matrix metallopeptidasesElastases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-11-26.

Open TargetsGene–disease associations from the Open Targets Platform.