NFE2L2

Gene

NFE2 like bZIP transcription factor 2

HGNCHGNC:7782 EnsemblENSG00000116044 NCBI Gene4780

Locus: gene with protein productLocation: 2q31.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Nuclear factor erythroid 2-related factor 2Q16236

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNRF2 · NRF-2

View full nomenclature history (6)

Alias symbolsNRF2, NRF-2

Previous namesnuclear factor (erythroid-derived 2)-like 2, nuclear factor, erythroid 2 like 2, nuclear factor, erythroid 2-like 2

Alias namesNF-E2-related factor 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Hepatocellular

Squamous cell lung carcinoma

Friedreich Ataxia

Squamous Cell Carcinoma of Head and Neck

Urinary Bladder Neoplasms

Lung carcinoma

Esophageal Squamous Cell Carcinoma

Endometrial Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MicroRNA protein coding host genesNFE2 family bZIP transcription factors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.