NSMCE2

Gene

NSE2 SUMO ligase component of SMC5/6 complex

HGNCHGNC:26513 EnsemblENSG00000156831 NCBI Gene286053

Locus: gene with protein productLocation: 8q24.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC8orf36 · FLJ32440 · MMS21 · NSE2 · ZMIZ7

View full nomenclature history (11)

Previous symbolsC8orf36

Alias symbolsFLJ32440, MMS21, NSE2, ZMIZ7

Previous namesNSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase, chromosome 8 open reading frame 36, non-SMC element 2 homolog (MMS21, S. cerevisiae), non-SMC element 2, MMS21 homolog (S. cerevisiae), NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase

Alias nameszinc finger, MIZ-type containing 7

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Seckel syndrome

Microcephalic primordial dwarfism

Neurodegenerative Diseases

Prostate carcinoma

Atrial Fibrillation

Placental abruption

Neuroendocrine Tumors

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers MIZ-typeSMC5/6 complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-06-16.

Open TargetsGene–disease associations from the Open Targets Platform.