OAS1

Gene

2'-5'-oligoadenylate synthetase 1

HGNCHGNC:8086 EnsemblENSG00000089127 NCBI Gene4938

Locus: gene with protein productLocation: 12q24.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asOIAS · OIASI · IFI-4

View full nomenclature history (6)

Previous symbolsOIAS

Alias symbolsOIASI, IFI-4

Previous names2',5'-oligoadenylate synthetase 1 (40-46 kD), 2'-5'-oligoadenylate synthetase 1, 40/46kDa

Alias names2'-5' oligoadenylate synthase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

COVID-19

Respiratory Insufficiency

Neurodegenerative Diseases

Spinal Cord Injuries

Macular Degeneration

Lupus Erythematosus, Systemic

Osteoarthritis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

2'-5'-oligoadenylate synthetase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-10-10.

Open TargetsGene–disease associations from the Open Targets Platform.