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P2RY12

Gene

purinergic receptor P2Y12

HGNCHGNC:18124EnsemblENSG00000169313NCBI Gene64805
Locus: gene with protein productLocation: 3q25.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

P2Y purinoceptor 12Q9H244

Protein · therapeutic target

Clinically validated target · 12 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asP2Y12 · SP1999 · HORK3
View full nomenclature history (4)
Alias symbolsP2Y12, SP1999, HORK3
Previous namespurinergic receptor P2Y, G-protein coupled, 12

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Platelet-type bleeding disorder 8
P2Y12 defect
Myocardial Infarction
Acute Coronary Syndrome
Coronary Artery Disease
Helicobacter Infections
Stroke
Peripheral Arterial Disease
Angina unstable

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

P2Y receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-01-15.
Open TargetsGene–disease associations from the Open Targets Platform.