PAM

Gene

peptidylglycine alpha-amidating monooxygenase

HGNCHGNC:8596 EnsemblENSG00000145730 NCBI Gene5066

Locus: gene with protein productLocation: 5q21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPAL · PHM · PAM-1

View full nomenclature history (5)

Alias symbolsPAL, PHM, PAM-1

Alias namespeptidyl-alpha-hydroxyglycine alpha-amidating lyase, peptidylglycine alpha-hydroxylating monooxygenase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2

Diabetes Mellitus

Diabetic Retinopathy

Diabetic Neuropathies

Alopecia

Intelligence

Diabetes Mellitus, Type 1

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

OxygenasesCarbon-nitrogen lyases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-05-24.

Open TargetsGene–disease associations from the Open Targets Platform.