PARP3

Gene

poly(ADP-ribose) polymerase family member 3

HGNCHGNC:273 EnsemblENSG00000041880 NCBI Gene10039

Locus: gene with protein productLocation: 3p21.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Protein mono-ADP-ribosyltransferase PARP3Q9Y6F1

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Member of “Poly(ADP-ribose) Polymerases” · 4 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asADPRTL3 · ADPRT3 · IRT1 · hPARP-3 · pADPRT-3 · ARTD3

View full nomenclature history (10)

Previous symbolsADPRTL3

Alias symbolsADPRT3, IRT1, hPARP-3, pADPRT-3, ARTD3

Previous namesADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3

Alias namespoly(ADP-ribose) synthetase-3, NAD+ ADP-ribosyltransferase 3, poly(ADP-ribose) polymerase 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Poly(ADP-ribose) polymerases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.