PDK1

Gene

pyruvate dehydrogenase kinase 1

HGNCHGNC:8809 EnsemblENSG00000152256 NCBI Gene5163

Locus: gene with protein productLocation: 2q31.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (2)

Previous namespyruvate dehydrogenase kinase, isoenzyme 1, pyruvate dehydrogenase kinase, isozyme 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pyruvate dehydrogenase kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-09-16.

Open TargetsGene–disease associations from the Open Targets Platform.