PLK1

Gene

polo like kinase 1

HGNCHGNC:9077 EnsemblENSG00000166851 NCBI Gene5347

Locus: gene with protein productLocation: 16p12.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPLK

View full nomenclature history (3)

Previous symbolsPLK

Previous namespolo-like kinase (Drosophila), polo-like kinase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Alzheimer's Disease

Parkinson's Disease

Lysosomal Storage Diseases

Multiple Sclerosis

Microcephaly

Epilepsy

Genetic developmental and epileptic encephalopathy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Polo like kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.