PTPN22

Gene

protein tyrosine phosphatase non-receptor type 22

HGNCHGNC:9652 EnsemblENSG00000134242 NCBI Gene26191

Locus: gene with protein productLocation: 1p13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tyrosine-protein phosphatase non-receptor type 22Q9Y2R2

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPTPN8 · Lyp · Lyp1 · Lyp2

View full nomenclature history (6)

Previous symbolsPTPN8

Alias symbolsLyp, Lyp1, Lyp2

Previous namesprotein tyrosine phosphatase, non-receptor type 8, protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Rheumatoid

Lupus Erythematosus, Systemic

Diabetes Mellitus, Type 1

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Protein tyrosine phosphatases non-receptor type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.