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RIC8B

Gene

RIC8 guanine nucleotide exchange factor B

HGNCHGNC:25555EnsemblENSG00000111785NCBI Gene55188
Locus: gene with protein productLocation: 12q23.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFLJ10620 · hSyn · RIC8
View full nomenclature history (4)
Alias symbolsFLJ10620, hSyn, RIC8
Previous namesresistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Atrial Fibrillation
Heart Arrest
Glaucoma, Open-Angle
Heart Failure
Cardiomyopathies
Glaucoma
Atrial Flutter
Arrhythmias, Cardiac

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Armadillo like helical domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.