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RTCB

Gene

RNA 2',3'-cyclic phosphate and 5'-OH ligase

HGNCHGNC:26935EnsemblENSG00000100220NCBI Gene51493
Locus: gene with protein productLocation: 22q12.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC22orf28 · TSLIG5 · HSPC117 · FAAP
View full nomenclature history (8)
Previous symbolsC22orf28
Alias symbolsTSLIG5, HSPC117, FAAP
Previous nameschromosome 22 open reading frame 28
Alias namesRNA-splicing ligase RtcB homolog, focal adhesion-associated protein, tRNA-splicing ligase RtcB homolog

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Lysosomal Storage Diseases
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Colitis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

tRNA splicing ligase complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-08.
Open TargetsGene–disease associations from the Open Targets Platform.