S100A8

Gene

S100 calcium binding protein A8

HGNCHGNC:10498 EnsemblENSG00000143546 NCBI Gene6279

Locus: gene with protein productLocation: 1q21.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Protein S100-A8P05109

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCAGA · CFAG · P8 · MRP8 · MRP-8 · 60B8AG · CGLA · S100-A8

View full nomenclature history (13)

Previous symbolsCAGA, CFAG

Alias symbolsP8, MRP8, MRP-8, 60B8AG, CGLA, S100-A8

Previous namescalgranulin A, cystic fibrosis antigen

Alias namesMigration inhibitory factor-related protein 8, Calprotectin L1L subunit, Leukocyte L1 complex light chain

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Immunologic Deficiency Syndromes

Lupus Erythematosus, Systemic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

S100 calcium binding proteinsEF-hand domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.