S1PR1

Gene

sphingosine-1-phosphate receptor 1

HGNCHGNC:3165 EnsemblENSG00000170989 NCBI Gene1901

Locus: gene with protein productLocation: 1p21.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sphingosine 1-phosphate receptor 1P21453

Protein · therapeutic target

Clinically validated target · 10 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asEDG1 · edg-1 · D1S3362 · CD363

View full nomenclature history (5)

Previous symbolsEDG1

Alias symbolsedg-1, D1S3362, CD363

Previous namesendothelial differentiation, sphingolipid G-protein-coupled receptor, 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Sclerosis

Colitis, Ulcerative

Multiple Sclerosis, Relapsing-Remitting

Multiple Sclerosis, Chronic Progressive

Lupus Erythematosus, Systemic

Crohn's Disease

Hypothyroidism

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sphingosine 1-phosphate receptorsCD molecules

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.