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S1PR5

Gene

sphingosine-1-phosphate receptor 5

HGNCHGNC:14299EnsemblENSG00000180739NCBI Gene53637
Locus: gene with protein productLocation: 19p13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sphingosine 1-phosphate receptor 5Q9H228

Protein · therapeutic target

Clinically validated target · 6 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asEDG8 · Edg-8
View full nomenclature history (3)
Previous symbolsEDG8
Alias symbolsEdg-8
Previous namesendothelial differentiation, sphingolipid G-protein-coupled receptor, 8

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Sclerosis
Colitis, Ulcerative
Multiple Sclerosis, Relapsing-Remitting
Crohn's Disease
Carcinoma, Non-Small-Cell Lung

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sphingosine 1-phosphate receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.