SEM1

Gene

SEM1 26S proteasome subunit

HGNCHGNC:10845 EnsemblENSG00000127922 NCBI Gene7979

Locus: gene with protein productLocation: 7q21.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

26S proteasome complex subunit SEM1P60896

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSHFD1 · SHFM1 · C7orf76 · DSS1 · Shfdg1 · ECD · SHSF1 · FLJ42280 · PSMD15

View full nomenclature history (13)

Previous symbolsSHFD1, SHFM1, C7orf76

Alias symbolsDSS1, Shfdg1, ECD, SHSF1, FLJ42280, PSMD15

Previous namessplit hand/foot malformation (ectrodactyly) type 1, chromosome 7 open reading frame 76, SEM1, 26S proteasome complex subunit

Alias namesdeleted in split-hand/foot 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ProteasomeTranscription and export complex 2

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.