SHANK2

Gene

SH3 and multiple ankyrin repeat domains 2

HGNCHGNC:14295 EnsemblENSG00000162105 NCBI Gene22941

Locus: gene with protein productLocation: 11q13.3-q13.4

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCORTBP1 · CTTNBP1 · ProSAP1 · SHANK · SPANK-3

View full nomenclature history (6)

Previous symbolsCORTBP1

Alias symbolsCTTNBP1, ProSAP1, SHANK, SPANK-3

Previous namescortactin binding protein 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Complex neurodevelopmental disorder

Autistic Disorder

Autism Spectrum Disorder

Diabetic Ketoacidosis

Alcohol drinking

Hodgkin's Disease

Neurodevelopmental Disorders

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ankyrin repeat domain containingSterile alpha motif domain containingPDZ domain containingMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.