SIM1

Gene

SIM bHLH transcription factor 1

HGNCHGNC:10882 EnsemblENSG00000112246 NCBI Gene6492

Locus: gene with protein productLocation: 6q16.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asbHLHe14

View full nomenclature history (4)

Alias symbolsbHLHe14

Previous namessingle-minded (Drosophila) homolog 1, single-minded homolog 1 (Drosophila), single-minded family bHLH transcription factor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Obesity disorder

Genetic Diseases, Inborn

Alopecia

Obesity due to melanocortin 4 receptor deficiency

Placental abruption

Hearing Loss

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Basic helix-loop-helix proteinsPAS domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.