SMO

Gene

smoothened, frizzled class receptor

HGNCHGNC:11119 EnsemblENSG00000128602 NCBI Gene6608

Locus: gene with protein productLocation: 7q32.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Protein smoothenedQ99835

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSMOH · FZD11

View full nomenclature history (7)

Previous symbolsSMOH

Alias symbolsFZD11

Previous namessmoothened, seven transmembrane spanning receptor, smoothened (Drosophila) homolog, smoothened homolog (Drosophila), smoothened, frizzled family receptor

Alias namesfrizzled family member 11

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Basal cell carcinoma

Leukemia, Myeloid, Acute

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

G protein-coupled receptors, Class F frizzled

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.