SPO11

Gene

SPO11 initiator of meiotic double strand breaks

HGNCHGNC:11250 EnsemblENSG00000054796 NCBI Gene23626

Locus: gene with protein productLocation: 20q13.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCT35 · SPATA43 · TOPVIA · TOPOVIA

View full nomenclature history (11)

Alias symbolsCT35, SPATA43, TOPVIA, TOPOVIA

Previous namesSPO11, meiotic protein covalently bound to DSB (S. cerevisiae)-like, SPO11 meiotic protein covalently bound to DSB-like (S. cerevisiae), SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae), SPO11 meiotic protein covalently bound to DSB, SPO11 initiator of meiotic double stranded breaks

Alias namescancer/testis antigen 35, spermatogenesis associated 43

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Placental abruption

Alopecia

Female infertility due to fertilization defect

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-05-18.

Open TargetsGene–disease associations from the Open Targets Platform.