TLR4

Gene

toll like receptor 4

HGNCHGNC:11850 EnsemblENSG00000136869 NCBI Gene7099

Locus: gene with protein productLocation: 9q33.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Toll-like receptor 4O00206

Protein · therapeutic target

Clinical-stage target · 3 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known ashToll · CD284 · TLR-4 · ARMD10

View full nomenclature history (5)

Alias symbolshToll, CD284, TLR-4, ARMD10

Previous namestoll-like receptor 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Major depressive disorder

Diabetes Mellitus, Type 2

Dengue

Colitis, Ulcerative

Immunologic Deficiency Syndromes

Psoriasis

Cholangitis, Sclerosing

Crohn's Disease

Spondylitis, Ankylosing

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesToll like receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.