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TLX3

Gene

T cell leukemia homeobox 3

HGNCHGNC:13532EnsemblENSG00000164438NCBI Gene30012
Locus: gene with protein productLocation: 5q35.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHOX11L2 · RNX
View full nomenclature history (5)
Previous symbolsHOX11L2
Alias symbolsRNX
Previous nameshomeo box 11-like 2, T-cell leukemia, homeobox 3, T-cell leukemia homeobox 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Colorectal adenocarcinoma
Gastric carcinoma
Carcinoma, Hepatocellular
Urinary bladder carcinoma
Leukemia, Myeloid, Acute
Esophageal Squamous Cell Carcinoma
Carcinoma, Non-Small-Cell Lung
Melanoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NKL subclass homeoboxes and pseudogenes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.