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TMPRSS3

Gene

transmembrane serine protease 3

HGNCHGNC:11877EnsemblENSG00000160183NCBI Gene64699
Locus: gene with protein productLocation: 21q22.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDFNB10 · DFNB8
View full nomenclature history (3)
Previous symbolsDFNB10, DFNB8
Previous namestransmembrane protease, serine 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hearing loss, autosomal recessive
Nonsyndromic genetic hearing loss
Deafness
Hearing Loss
Genetic Diseases, Inborn
Non-syndromic genetic deafness
Presbycusis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Scavenger receptor cysteine rich domain containingType II transmembrane serine proteases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.