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TNFRSF11B

Gene

TNF receptor superfamily member 11b

HGNCHGNC:11909EnsemblENSG00000164761NCBI Gene4982
Locus: gene with protein productLocation: 8q24.12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tumor necrosis factor receptor superfamily member 11BO00300

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asOPG · OCIF · TR1
View full nomenclature history (6)
Previous symbolsOPG
Alias symbolsOCIF, TR1
Previous namesosteoprotegerin, tumor necrosis factor receptor superfamily, member 11b
Alias namesosteoclastogenesis inhibitory factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Osteoporosis
Hypothyroidism
Myxedema
Nasal Polyps
Fractures, Bone
Bone Diseases
Autoimmune Diseases
Thyroid Diseases
Hashimoto's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Tumor necrosis factor receptor superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.