TNFSF4

Gene

TNF superfamily member 4

HGNCHGNC:11934 EnsemblENSG00000117586 NCBI Gene7292

Locus: gene with protein productLocation: 1q25.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tumor necrosis factor ligand superfamily member 4P23510

Protein · therapeutic target

Clinical-stage target · 2 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTXGP1 · OX-40L · gp34 · CD252

View full nomenclature history (6)

Previous symbolsTXGP1

Alias symbolsOX-40L, gp34, CD252

Previous namestax-transcriptionally activated glycoprotein 1, 34kD, tumor necrosis factor (ligand) superfamily, member 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lupus Erythematosus, Systemic

Asthma

Dermatitis, Atopic

Rhinitis, Allergic

Arthritis, Rheumatoid

Childhood onset asthma

Respiratory Tract Diseases

Hypersensitivity

Venous Thrombosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesTumor necrosis factor superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.