TRAF6

Gene

TNF receptor associated factor 6

HGNCHGNC:12036 EnsemblENSG00000175104 NCBI Gene7189

Locus: gene with protein productLocation: 11p12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

TNF receptor-associated factor 6Q9Y4K3

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRNF85

View full nomenclature history (3)

Alias symbolsRNF85

Previous namesTNF receptor-associated factor 6, E3 ubiquitin protein ligase

Alias namesRING finger protein 85

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Severe Acute Respiratory Syndrome

Ovarian neoplasm

Chronic Kidney Disease-Mineral and Bone Disorder

Neoplasms

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsTNF receptor associated factorsZinc fingers TRAF-type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.