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USP53

Gene

ubiquitin specific peptidase 53

HGNCHGNC:29255EnsemblENSG00000145390NCBI Gene54532
Locus: gene with protein productLocation: 4q26

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA1350
View full nomenclature history (2)
Alias symbolsKIAA1350
Previous namesubiquitin specific protease 53

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cholestasis
Deafness
Joint Diseases
Genetic Diseases, Inborn
Coronary Artery Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ubiquitin specific peptidases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.