Anaphylaxis
Recent clinical, regulatory, research and industry developments relating to this disease.
Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 2 clinical trials expected to report results, the earliest in Q4 2026.
- 2 industry developments reported.
- Q4 2026Evaluation of Emergency Medication in Children With Food Allergies: a Prospective, Randomized Clinical Multicenter Study Comparing Antihistamines Versus Antihistamines Plus Steroids in a Controlled Setting of Oral Food Challenges in Children.
- Q3 2028Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
Clinical MilestonesViewHide
- 2026-05-26Optimizing the Diagnostic Approach to Cephalosporin Allergy TestingResults expected Q3 2028
- 2026-01-27Evaluation of Emergency Medication in Children With Food Allergies: a Prospective, Randomized Clinical Multicenter Study Comparing Antihistamines Versus Antihistamines Plus Steroids in a Controlled Setting of Oral Food Challenges in Children.Results expected Q4 2026
- 2026-06-01A Phase 1b, Open-Label, Exploratory Study Evaluating the Effects of Inhaled Epinephrine in Individuals Experiencing Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral ChallengesPrimary completion
- 2025-11-01A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut AllergyPrimary completion
Industry & MarketViewHide
- 2026-09-16Wales takes UK lead on needle-free anaphylaxis preventionIndustry · pharmaphorum
- 2026-09-03Lipid-Lowering Drugs Tied to Worse Venom AnaphylaxisIndustry · Medscape Medical News
- 2026-09-16IndustryWales takes UK lead on needle-free anaphylaxis preventionIndustry · pharmaphorum
- 2026-09-03IndustryLipid-Lowering Drugs Tied to Worse Venom AnaphylaxisIndustry · Medscape Medical News
- 2026-06-01ClinicalA Phase 1b, Open-Label, Exploratory Study Evaluating the Effects of Inhaled Epinephrine in Individuals Experiencing Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral ChallengesPrimary completion
- 2026-05-26ClinicalOptimizing the Diagnostic Approach to Cephalosporin Allergy TestingResults expected Q3 2028
- 2026-01-27ClinicalEvaluation of Emergency Medication in Children With Food Allergies: a Prospective, Randomized Clinical Multicenter Study Comparing Antihistamines Versus Antihistamines Plus Steroids in a Controlled Setting of Oral Food Challenges in Children.Results expected Q4 2026
- 2025-11-01ClinicalA Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut AllergyPrimary completion
Therapeutic landscape
Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.
Approval — Eurneffy is indicated in the emergency treatment of allergic reactions (anaphylaxis) due… (2024)
Clinical trials
The current development programme across all trial phases.
Regulatory timeline
Drug regulatory events matched to this condition by indication — EMA.
European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Leading journals1
- The New England journal of medicine1
Leading researchers8
- Berlin J1
- Chan E1
- Chung CH1
- Gold D1
- Hatley T1
- Hicklin DJ1
- Hosen J1
- Le QT1
Affiliations (unnormalised)1
- Vanderbilt University School of Medicine1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Reference
Authoritative identity, definition & identifiers.
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.