Carcinogenesis
Recent clinical, regulatory, research and industry developments relating to this disease.
The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development.
Stomach microbiota in gastric cancer development and clinical implications.
RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms.
Periodontal pathogens and cancer development.
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets.
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy.
The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs.
Cholesterol metabolism in tumor microenvironment: cancer hallmarks and therapeutic opportunities.
NSCLC: from tumorigenesis, immune checkpoint misuse to current and future targeted therapy.
Amino acid metabolism in tumor biology and therapy.
Intratumoural microbiota: a new frontier in cancer development and therapy.
Insights into the Tumor Microenvironment-Components, Functions and Therapeutics.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Research-associated treatments
Drugs and agents co-studied with this disease across the research literature — associative, not necessarily established treatments. Number shows shared papers.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Neoplasms20
- Carcinogenesis8
- Colorectal Neoplasms5
- Gastrointestinal Microbiome5
- Microbiota4
- Tumor Microenvironment4
- Breast Neoplasms3
- Cell Transformation, Neoplastic3
Leading journals6
- Signal transduction and targeted therapy7
- Frontiers in immunology4
- Journal of hematology & oncology4
- Cell communication and signaling : CCS3
- International journal of molecular sciences3
- Molecular cancer3
Leading researchers8
- Li X4
- Li Y4
- Zhang Y4
- Chen L3
- Liu S3
- Liu Y3
- Liu Z3
- Wang X3
Affiliations (unnormalised)6
- School of Medicine4
- The University of Texas MD Anderson Cancer Center3
- Cancer Center2
- Howard Hughes Medical Institute2
- Icahn School of Medicine at Mount Sinai2
- Imperial College London2
Disease biology
Key proteins & gene products studied in this disease. Number shows shared papers.
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Carcinogenesis is the origin and development of cancer through genotypic and phenotypic changes that disrupt the normal balance between cell proliferation and cell death. It is generally a multistep process that can unfold rapidly or over many years.
The supplied grounding supports chronic inflammation as a contributor to malignant transformation and carcinogenesis. It also supports microbial involvement in some cancers through the microbiome, although the number of microbes known to directly cause carcinogenesis is described as small.
Carcinogenesis involves accumulated genetic and phenotypic changes that promote uncontrolled proliferation and resistance to cell death. The grounding links this process to altered signal transduction, oncogenic pathways, oxidative stress, apoptosis dysregulation, epithelial-mesenchymal transition, and tumor microenvironment interactions that support invasion, metastasis, and progression.
Chronic inflammation is supported as a factor that can promote malignant transformation and carcinogenesis. The grounding also supports involvement of the microbiome in cancer-related processes, but it does not establish specific general risk factors beyond this.
AI-generated summary grounded in MeSH and 6 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.