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Disease

Intestinal Obstruction

Late-stage therapeutic developmentEmerging research
MeSHIntestinal Obstruction
2
Publications
8
Clinical trials
12
Associated genes
2
Related proteins
2024
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

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Clinical trials

6 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
8
All trials
0
Active
2
Late-stage
6
Completed
Recently completed

The Effects of Preoperative High-dose Dexamethasone on Inflammatory Response and Recovery After Emergency Laparotomy, a Randomized, Double-blind, Placebo-controlled Clinical Trial - AHA STEROID TRIAL

Phase 4 · Completed · Mirjana Cihoric

An International, Multicentric, Prospective, Open Label Study to Assess the Efficacy and Safety of Lanreotide Autogel 120 MG Associated to Standard of Care in the Treatment of Clinical Symptoms Associated With Inoperable Malignant Intestinal Obstruction

Phase 2 · Completed · Ipsen

Prospective Study to Assess the Efficacy and Safety of Lanreotide 120 mg as a Palliative Treatment of Clinical Symptoms Associated With Malignant Intestinal Obstruction in Inoperable Patients

Phase 2 · Completed · University Hospital, Ghent

Effects of Extended Release Methylnaltrexone Bromide (150 mg b.i.d.) in Comparison to Extended Release Naloxone Hydrochloride (20 mg b.i.d.) on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time in Healthy Subjects.

Phase 1 · Completed · University Medicine Greifswald

Phase III, Multicentre, Randomised, Double-blind, Comparative Study to Assess the Efficacy and Safety of Lanreotide 30 mg Versus Placebo as a Palliative Treatment of Clinical Symptoms Associated With Intestinal Obstruction Due to Peritoneal Carcinomatosis in Inoperable Patients.

Phase 3 · Completed · Ipsen

Evaluation of the Effect of Octreotide Compared to Placebo in Patients With Inoperable Bowel Obstruction Due to Peritoneal Carcinomatosis

Phase 2 · Completed · Novartis Pharmaceuticals

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20202024
Most influential

Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2020.

Endoscopy · 2020 · 213 cites

Use of DPP4 Inhibitors and GLP-1 Receptor Agonists and Risk of Intestinal Obstruction: Scandinavian Cohort Study.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024 · 21 cites
Recent publications

Use of DPP4 Inhibitors and GLP-1 Receptor Agonists and Risk of Intestinal Obstruction: Scandinavian Cohort Study.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024 · 21 cites

Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2020.

Endoscopy · 2020 · 213 cites
Major themes5
  • Intestinal Obstruction2
  • Colonic Neoplasms1
  • Dipeptidyl-Peptidase IV Inhibitors1
  • Glucagon-Like Peptide-1 Receptor Agonists1
  • Self Expandable Metallic Stents1
Leading journals2
  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association1
  • Endoscopy1
Leading researchers8
  • Arezzo A1
  • Arnold D1
  • Beets-Tan RGH1
  • Eliasson B1
  • Everett S1
  • Götz M1
  • Gudbjörnsdottir S1
  • Hill J1
Affiliations (unnormalised)6
  • Centre Hospitalier Universitaire de l'Archet1
  • Centro Hospitalar São João1
  • Clinical Epidemiology Division1
  • Department of Molecular and Clinical Medicine1
  • Digestive Disease Center1
  • Guido Salvini Hospital1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

SLC26A30.43DKK20.32ASB180.29HMBOX10.27GRAMD1A0.27MDGA10.26PSME40.26RSBN10.25MKI670.24RPL380.21ZBTB460.19GARRE10.17

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Proliferation marker protein Ki-67via MKI670.24Large ribosomal subunit protein eL38via RPL380.21

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.

Identifiers
MeSHIntestinal Obstruction
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.