Back to discover
Disease
Scoliosis
Late-stage therapeutic developmentEmerging research
1
Publications
21
Clinical trials
12
Associated genes
3
Related proteins
2023
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Can Artificial Intelligence Improve the Readability of Patient Education Materials?
Research2023-04-28Clinical orthopaedics and related research
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 3 clinical trials expected to report results, the earliest in Q1 2027.
- 2 industry developments reported.
Upcoming Milestones
- Q1 2027The Effect of Erector Spinae Plane Block (ESPB) on Pediatric Pain Management Following Posterior Spinal Fusion (PSF) Surgery
- Q3 2027IntraVenous Iron in Kids With Iron Deficiency and Scoliosis
- Q1 2029Prospective Randomized Evaluation of Analgesia for Spine Fusion Elective Surgery in Children (PRECISE Spine Trial)
Major developments
Upcoming trial readoutHigh impact
Results expected Q1 20292026-05-05
Upcoming trial readoutHigh impact
Results expected Q1 20272026-05-01
Clinical MilestonesView all 9Hide
Results expected
- 2026-05-05Prospective Randomized Evaluation of Analgesia for Spine Fusion Elective Surgery in Children (PRECISE Spine Trial)Results expected Q1 2029
- 2026-05-01The Effect of Erector Spinae Plane Block (ESPB) on Pediatric Pain Management Following Posterior Spinal Fusion (PSF) SurgeryResults expected Q1 2027
- 2025-11-26IntraVenous Iron in Kids With Iron Deficiency and ScoliosisResults expected Q3 2027
Recently completed
- 2026-07-31A Comparison Between Palonosetron Versus Granisetron As Postoperative Nausea and Vomiting Prophylaxis In Idiopathic Scoliosis Surgery: A Randomized Control TrialPrimary completion
- 2026-04-01The Impact of Perioperative Steroid Dosing on the Acute Phase Response in Adolescent Idiopathic ScoliosisCompleted
- 2026-03-31Dexmedetomidine for ESPB in Pain Management After Pediatric IdiopathicCompleted
- 2025-10-23Efficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind TrialPrimary completion
- 2025-10-07Dexamethasone for ESPB in Pain Management After Pediatric IdiopathicCompleted
Other updates
+1 more in the activity timeline below
Industry & MarketViewHide
- 2026-08-26How Many Hours Are Enough? Rethinking Brace Prescriptions in Adolescent Idiopathic ScoliosisIndustry · Orthopedics This Week
- 2026-08-17Global Scoliosis: 5.4 Million Kids and a Few SurprisesIndustry · Orthopedics This Week
Activity timeline11
- 2028-05-01ClinicalUse of a Buffered 2% Hypertonic Saline Solution During Posterior Spinal FusionWithdrawn
- 2026-08-26IndustryHow Many Hours Are Enough? Rethinking Brace Prescriptions in Adolescent Idiopathic ScoliosisIndustry · Orthopedics This Week
- 2026-08-17IndustryGlobal Scoliosis: 5.4 Million Kids and a Few SurprisesIndustry · Orthopedics This Week
- 2026-07-31ClinicalA Comparison Between Palonosetron Versus Granisetron As Postoperative Nausea and Vomiting Prophylaxis In Idiopathic Scoliosis Surgery: A Randomized Control TrialPrimary completion
- 2026-05-05ClinicalProspective Randomized Evaluation of Analgesia for Spine Fusion Elective Surgery in Children (PRECISE Spine Trial)Results expected Q1 2029
- 2026-05-01ClinicalThe Effect of Erector Spinae Plane Block (ESPB) on Pediatric Pain Management Following Posterior Spinal Fusion (PSF) SurgeryResults expected Q1 2027
- 2026-04-01ClinicalThe Impact of Perioperative Steroid Dosing on the Acute Phase Response in Adolescent Idiopathic ScoliosisCompleted
- 2026-03-31ClinicalDexmedetomidine for ESPB in Pain Management After Pediatric IdiopathicCompleted
- 2025-11-26ClinicalIntraVenous Iron in Kids With Iron Deficiency and ScoliosisResults expected Q3 2027
- 2025-10-23ClinicalEfficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind TrialPrimary completion
Clinical trials
The current development programme across all trial phases.
Clinical programme
21
6
15
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes2
- Health Literacy1
- Scoliosis1
Leading journals1
- Clinical orthopaedics and related research1
Leading researchers4
- Bible JE1
- Kim RY1
- Kirchner GJ1
- Weddle JB1
Affiliations (unnormalised)1
- Penn State Milton S. Hershey Medical Center1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.