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Disease

Scoliosis

Late-stage therapeutic developmentEmerging research
MeSHScoliosis
1
Publications
21
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Can Artificial Intelligence Improve the Readability of Patient Education Materials?

Research2023-04-28Clinical orthopaedics and related research

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 3 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Prospective Randomized Evaluation of Analgesia for Spine Fusion Elective Surgery in Children (PRECISE Spine Trial)
Results expected Q1 20292026-05-05
Upcoming trial readoutHigh impact
The Effect of Erector Spinae Plane Block (ESPB) on Pediatric Pain Management Following Posterior Spinal Fusion (PSF) Surgery
Results expected Q1 20272026-05-01
Clinical Milestones9View all 9
Results expected 3
Recently completed 5
Other updates 1
+1 more in the activity timeline below
Activity timeline9

Clinical trials

15 sponsors · 3 new · 3 completed in the last 12 months (net +3)

The current development programme across all trial phases.

Clinical programme
21
All trials
6
Active
14
Late-stage
6
Completed
Late-stage studies

Pooled Human Plasma vs Crystalloid in The Management of Children Undergoing Instrumented Spinal Fusion for Scoliosis: A Double-Blind, Randomized Clinical Trial

Phase 3 · Recruiting · Turku University Hospital

Prospective Randomized Evaluation of Analgesia for Spine Fusion Elective Surgery in Children (PRECISE Spine Trial)

Phase 3 · Recruiting · Senthil Sadhasivam

IntraVenous Iron in Kids With Iron Deficiency and Scoliosis

Phase 2/3 · Recruiting · Columbia University

A Comparison Between Palonosetron Versus Granisetron As Postoperative Nausea and Vomiting Prophylaxis In Idiopathic Scoliosis Surgery: A Randomized Control Trial

Phase 4 · Recruiting · University of Malaya

The Effect of Erector Spinae Plane Block (ESPB) on Pediatric Pain Management Following Posterior Spinal Fusion (PSF) Surgery

Phase 3 · Recruiting · University of California, San Francisco

The Impact of Perioperative Steroid Dosing on the Acute Phase Response in Adolescent Idiopathic Scoliosis

Phase 4 · Completed · Emory University
Recruiting

Pooled Human Plasma vs Crystalloid in The Management of Children Undergoing Instrumented Spinal Fusion for Scoliosis: A Double-Blind, Randomized Clinical Trial

Phase 3 · Recruiting · Turku University Hospital

Prospective Randomized Evaluation of Analgesia for Spine Fusion Elective Surgery in Children (PRECISE Spine Trial)

Phase 3 · Recruiting · Senthil Sadhasivam

IntraVenous Iron in Kids With Iron Deficiency and Scoliosis

Phase 2/3 · Recruiting · Columbia University

A Comparison Between Palonosetron Versus Granisetron As Postoperative Nausea and Vomiting Prophylaxis In Idiopathic Scoliosis Surgery: A Randomized Control Trial

Phase 4 · Recruiting · University of Malaya

The Effect of Erector Spinae Plane Block (ESPB) on Pediatric Pain Management Following Posterior Spinal Fusion (PSF) Surgery

Phase 3 · Recruiting · University of California, San Francisco

The Role of VitD in Rehabilitation of Idiopathic Adolescent Scoliosis

Phase 2 · Recruiting · University of Ioannina
Recently completed

The Impact of Perioperative Steroid Dosing on the Acute Phase Response in Adolescent Idiopathic Scoliosis

Phase 4 · Completed · Emory University

Dexmedetomidine for ESPB in Pain Management After Pediatric Idiopathic

Phase 4 · Completed · Poznan University of Medical Sciences

Dexamethasone for ESPB in Pain Management After Pediatric Idiopathic

Phase 4 · Completed · Poznan University of Medical Sciences

A Single-center, Randomized, Single-blind Pilot Study to Evaluate Intravenous Methadone Versus EXPAREL Erector Spinae Plane Blockade in Pediatric Subjects Undergoing Adolescent and Juvenile Idiopathic Scoliosis Correction

Phase 4 · Completed · Dr. Casey Stondell, MD

Perioperative Multimodal Analgesia Including Intravenous Lidocaine Infusion for Pain Management Following Idiopathic Scoliosis Correction Surgery in Children

Phase 3 · Completed · University of British Columbia

A Comparison Between Palonosetron And Ondansetron As Prophylaxis Against Postoperative Nausea and Vomiting In Idiopathic Scoliosis Surgery: A Randomised Trial

Phase 4 · Completed · University of Malaya

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Can Artificial Intelligence Improve the Readability of Patient Education Materials?

Clinical orthopaedics and related research · 2023 · 118 cites
Recent publications

Can Artificial Intelligence Improve the Readability of Patient Education Materials?

Clinical orthopaedics and related research · 2023 · 118 cites
Major themes2
  • Health Literacy1
  • Scoliosis1
Leading journals1
  • Clinical orthopaedics and related research1
Leading researchers4
  • Bible JE1
  • Kim RY1
  • Kirchner GJ1
  • Weddle JB1
Affiliations (unnormalised)1
  • Penn State Milton S. Hershey Medical Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)

Identifiers
MeSHScoliosis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.