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HARS1

Gene

histidyl-tRNA synthetase 1

HGNCHGNC:4816EnsemblENSG00000170445NCBI Gene3035
Locus: gene with protein productLocation: 5q31.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asUSH3B · HARS · HisRS
View full nomenclature history (7)
Previous symbolsUSH3B, HARS
Alias symbolsHisRS
Previous namesUsher syndrome 3B, histidyl-tRNA synthetase
Alias nameshistidine tRNA ligase 1, cytoplasmic, Jo‐1 antigen

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cerebellar Ataxia
Microcephaly
Scoliosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Aminoacyl tRNA synthetases, Class II

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.