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Drug

Mirvetuximab soravtansine

Approved · EMA
ClassTubulin inhibitorEmerging researchLate-stage developmentRising momentum

Also known as Elahere.

3
Research papers
8
Active clinical trials
16
Protein targets
1
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Approval: Elahere (EMA)

Regulatory2024-11-14EMA

Mirvetuximab soravtansine-gynx: first antibody/antigen-drug conjugate (ADC) in advanced or recurrent ovarian cancer.

Research2024-04-01International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Mirvetuximab soravtansine
Aliases & brands
Elahere
RxNorm CUI
2621548
ChEMBL ID
CHEMBL3545132
ATC codes
L01FX26
UNII
98DE7VN88D
Primary mechanism
Tubulin inhibitor
Regulatory jurisdictions
ema

Pharmacology & targets

16 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Tubulin beta-4B chain
TUBB4B · P68371
INHIBITORTubulin inhibitor
Tubulin beta-1 chain
TUBB1 · Q9H4B7
INHIBITORTubulin inhibitor
Tubulin alpha-3C chain
TUBA3C · P0DPH7
INHIBITORTubulin inhibitor
Tubulin alpha-4A chain
TUBA4A · P68366
INHIBITORTubulin inhibitor
Tubulin beta-3 chain
TUBB3 · Q13509
INHIBITORTubulin inhibitor
Tubulin alpha-1A chain
TUBA1A · Q71U36
INHIBITORTubulin inhibitor
Tubulin beta-4A chain
TUBB4A · P04350
INHIBITORTubulin inhibitor
Tubulin beta-8 chain
TUBB8 · Q3ZCM7
INHIBITORTubulin inhibitor
Tubulin beta chain
TUBB · P07437
INHIBITORTubulin inhibitor
Tubulin alpha-1B chain
TUBA1B · P68363
INHIBITORTubulin inhibitor
Tubulin alpha-1C chain
TUBA1C · Q9BQE3
INHIBITORTubulin inhibitor
Tubulin alpha-3E chain
TUBA3E · Q6PEY2
INHIBITORTubulin inhibitor
Tubulin beta-2A chain
TUBB2A · Q13885
INHIBITORTubulin inhibitor
Tubulin beta-2B chain
TUBB2B · Q9BVA1
INHIBITORTubulin inhibitor
Tubulin beta-6 chain
TUBB6 · Q9BUF5
INHIBITORTubulin inhibitor
Folate receptor alpha
FOLR1 · P15328
BINDING AGENTFolate receptor alpha binding agent

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
2024-11-14
Latest approval
2024-11-14
Authorities
EMA
Total events
1
emaEuropean Medicines Agency· 1 event
2024-11-14Approval
Approval: Elahere (EMA)
Indication: Elahere as monotherapy is indicated for the treatment of adult patients with folate receptor-alpha (FRα) positive, platinum-resistant high grade serous epithelial ovarian,Show full indication

Elahere as monotherapy is indicated for the treatment of adult patients with folate receptor-alpha (FRα) positive, platinum-resistant high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to three prior systemic treatment regimens.

Evidence ↗

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

20 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
20
registered trials across all phases
LATEST COMPLETION 2024
8
Active studies
6
Recruiting
5
Late-stage (III+)
9
Completed
3
Discontinued
PHASE DISTRIBUTIONn = 20
Phase 14Phase 1 / 21Phase 210Phase 35

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20232025
Most influential

Mirvetuximab soravtansine-gynx: first antibody/antigen-drug conjugate (ADC) in advanced or recurrent ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024 · 34 cites
Recent papers

Mirvetuximab soravtansine-gynx: first antibody/antigen-drug conjugate (ADC) in advanced or recurrent ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024 · 34 cites
Major research themes8
Ovarian Neoplasms3Immunoconjugates2Antibodies, Monoclonal, Humanized1Antineoplastic Agents1Carcinoma, Ovarian Epithelial1Fallopian Tube Neoplasms1Folate Receptor 11Maytansine1
Journals, researchers & institutions
Top journals
  • Gynecologic oncology1
  • International journal of gynecological cancer : official journal of the International Gynecological Cancer Society1
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology1
Leading researchers
  • Coleman RL2
  • Oaknin A2
  • Armetta J1
  • Biorn M1
  • Bogani G1
  • Caveney B1
  • Colombo N1
  • Cooper M1
Leading institutions
free-text, unnormalised
  • Bon Secours Hospital and Clinical Trials1
  • Centre Leon Berard1
  • Dana Farber Cancer Institute1
  • Dana-Farber Cancer Institute1
  • European Institute of Oncology IRCCS1
  • Fondazione Policlinico Universitario A. Gemelli1

Related diseases

2 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 5 of the same disease areas as Mirvetuximab soravtansine in the shared literature.

5 shared diseases3 shared papers
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.