Back to discover
Drug

Tyrosine

In clinical development
Emerging researchLate-stage developmentCooling momentum
Also known as (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid, (S)-(-)-Tyrosine, (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid, (S)-3-(p-Hydroxyphenyl)alanine+41 more

(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid, (S)-(-)-Tyrosine, (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid, (S)-3-(p-Hydroxyphenyl)alanine, (S)-Tyrosine, (S)-alpha-amino-4-Hydroxybenzenepropanoic acid, 4-hydroxy-L-phenylalanine, Aminosyn 10%, Sulfite-Free, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn 8.5%, Sulfite-Free, Aminosyn II 10 %, Aminosyn II 15%, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 %, Sulfite-Free, Aminosyn-HBC 7 %, Sulfite-Free, Aminosyn-PF 10 %, Sulfite-Free, Aminosyn-PF 7%, Clinisol 15, L-Tyrosin, L-Tyrosine, Plenamine, PremaSol, ProSol, Tirosina, Travasol 10, Travasol 10%, Trophamine, Trophamine 10 %, Trophamine 6 %, Tyr, Y, Clinimix 4.25/10, Clinimix 4.25/25, Clinimix 4.25/5, Clinimix 5/15, Clinimix 5/20, Clinimix 5/25, Clinimix E 2.75/5, Clinimix E 4.25/10, Clinimix E 4.25/5, Clinimix E 5/15, Clinimix E 5/20, Clinimix E 5/25, Tyrosinum.

6
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Contribution of L-Tyrosine to Human Decision Making in Stressful Situations

Clinical trial2022-04-07Completed · ClinicalTrials.gov

The Precision Hypertension Care Study

Clinical trial2021-06-11Completed · ClinicalTrials.gov

Treatment of TNNT1-Myopathy With L-Tyrosine. A Double-blind, Placebo-controlled Crossover Trial.

Clinical trial2015-01-01Primary completion · ClinicalTrials.gov

L-Tyrosine Supplementation in Patients With Fibromyalgia

Clinical trial2011-01-01Terminated · ClinicalTrials.gov

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

Research2002-03-01The Journal of neuroscience : the official journal of the Society for Neuroscience

Oxidative damage is the earliest event in Alzheimer disease.

Research2001-08-01Journal of neuropathology and experimental neurology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Tyrosine
Aliases & brands
(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid(S)-(-)-Tyrosine(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid(S)-3-(p-Hydroxyphenyl)alanine(S)-Tyrosine(S)-alpha-amino-4-Hydroxybenzenepropanoic acid4-hydroxy-L-phenylalanineAminosyn 10%, Sulfite-FreeAminosyn 3.5 % M, Sulfite FreeAminosyn 8.5 % with Electrolytes, Sulfite-FreeAminosyn 8.5%, Sulfite-FreeAminosyn II 10 %Aminosyn II 15%Aminosyn II 8.5 % with Electrolytes, Sulfite-FreeAminosyn II 8.5 %, Sulfite-FreeAminosyn-HBC 7 %, Sulfite-FreeAminosyn-PF 10 %, Sulfite-FreeAminosyn-PF 7%Clinisol 15L-TyrosinL-TyrosinePlenaminePremaSolProSolTirosinaTravasol 10Travasol 10%TrophamineTrophamine 10 %Trophamine 6 %TyrYClinimix 4.25/10Clinimix 4.25/25Clinimix 4.25/5Clinimix 5/15Clinimix 5/20Clinimix 5/25Clinimix E 2.75/5Clinimix E 4.25/10Clinimix E 4.25/5Clinimix E 5/15Clinimix E 5/20Clinimix E 5/25Tyrosinum
RxNorm CUI
10962
ChEMBL ID
CHEMBL925
UNII
42HK56048U

Clinical trials

7 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
7
registered trials across all phases
LATEST COMPLETION 2022
6
Late-stage (III+)
3
Completed
4
Discontinued
PHASE DISTRIBUTIONn = 7
Phase 21Phase 41Phase N / A5

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Precision Hypertension Care Study

CompletedPH IVUppsala Universityn=2802021

Recent completions

Trials that read out recently, adding to the completed evidence base.

Contribution of L-Tyrosine to Human Decision Making in Stressful Situations

CompletedN/ADirection Centrale du Service de Santé des Arméesn=172022

Contribution of L-Tyrosine to Recovery From Operational Strain on Return From External Operation

CompletedN/ADirection Centrale du Service de Santé des Arméesn=1162021

The Precision Hypertension Care Study

CompletedPH IVUppsala Universityn=2802021

Research activity

6 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19972023
Most influential
Recent papers
Major research themes4
Oxidative Stress2Angioplasty, Balloon, Coronary1Gastrointestinal Microbiome1Myocardial Infarction1
Journals, researchers & institutions
Top journals
  • The Journal of neuroscience : the official journal of the Society for Neuroscience2
  • European heart journal1
  • Journal of neuropathology and experimental neurology1
  • PloS one1
  • The New England journal of medicine1
Leading researchers
  • Perry G2
  • Smith MA2
  • Aliev G1
  • Atwood CS1
  • Bäckhed F1
  • Balraj EK1
  • Beckman JS1
  • Braunwald E1
Leading institutions
free-text, unnormalised
  • Institute of Pathology2
  • and Thoracic Institute1
  • Biomedical Innovation Academy1
  • Brigham and Women's Hospital1
  • Center for Microbiome & Human Health1
  • Center for Regenerative Therapies1

Related diseases

2 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 2 of the same disease areas as Tyrosine in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Tyrosine in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Tyrosine in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Tyrosine in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Tyrosine in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Tyrosine in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Tyrosine in the shared literature.

2 shared diseases1 shared paper

Studied across the same disease area as Tyrosine in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials