BACE2

Gene

beta-secretase 2

HGNCHGNC:934 EnsemblENSG00000182240 NCBI Gene25825

Locus: gene with protein productLocation: 21q22.2-q22.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAEPLC · ASP1 · DRAP · ALP56 · CEAP1

View full nomenclature history (11)

Previous symbolsAEPLC

Alias symbolsASP1, DRAP, ALP56, CEAP1

Previous namesbeta-site APP-cleaving enzyme 2

Alias namesmemapsin 1, theta-secretase, aspartyl protease 1, 56 kDa aspartic-like protease, Down region aspartic protease

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Essential Tremor

Diabetes Mellitus, Type 2

Sleep Initiation and Maintenance Disorders

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Peptidase family A1

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-11-20.

Open TargetsGene–disease associations from the Open Targets Platform.