CTLA4

Gene

cytotoxic T-lymphocyte associated protein 4

HGNCHGNC:2505 EnsemblENSG00000163599 NCBI Gene1493

Locus: gene with protein productLocation: 2q33.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Cytotoxic T-lymphocyte protein 4P16410

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCELIAC3 · IDDM12 · CD152 · CD · GSE · CTLA-4

View full nomenclature history (10)

Previous symbolsCELIAC3, IDDM12

Alias symbolsCD152, CD, GSE, CTLA-4

Previous namesceliac disease 3, insulin-dependent diabetes mellitus 12

Alias namesgluten-sensitive enteropathy, celiac disease

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency

Hashimoto's Disease

Lupus Erythematosus, Systemic

Melanoma

Carcinoma, Non-Small-Cell Lung

Carcinoma, Hepatocellular

Arthritis, Rheumatoid

Hypothyroidism

Diabetes Mellitus, Type 1

Graves' Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesV-set domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-06-19.

Open TargetsGene–disease associations from the Open Targets Platform.