FURIN

Gene

furin, paired basic amino acid cleaving enzyme

HGNCHGNC:8568 EnsemblENSG00000140564 NCBI Gene5045

Locus: gene with protein productLocation: 15q26.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPCSK3 · FUR · PACE · SPC1

View full nomenclature history (8)

Previous symbolsPCSK3, FUR, PACE

Alias symbolsSPC1

Previous namespaired basic amino acid cleaving enzyme (furin, membrane associated receptor protein), furin (paired basic amino acid cleaving enzyme)

Alias namesproprotein convertase subtilisin/kexin 3, subtilisin-like proprotein convertase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Coronary Artery Disease

Hypertension

Myocardial Infarction

Myocardial Ischemia

COVID-19

Angina Pectoris

Cardiovascular Diseases

Essential Hypertension

Heart Diseases

Alcohol drinking

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proprotein convertase subtilisin/kexin family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.