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HECW1

Gene

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

HGNCHGNC:22195EnsemblENSG00000002746NCBI Gene23072
Locus: gene with protein productLocation: 7p14.1-p13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA0322 · NEDL1
View full nomenclature history (2)
Alias symbolsKIAA0322, NEDL1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2
Placental abruption
Metabolic Diseases
Chronic Kidney Disease-Mineral and Bone Disorder
Male reproductive organ cancer
Colitis, Ulcerative
Inflammatory Bowel Diseases
Obesity disorder
Tooth disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

C2 domain containingMicroRNA protein coding host genesNedd4 family E3 ubiquitin protein ligases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.