KMT5B

Gene

lysine methyltransferase 5B

HGNCHGNC:24283 EnsemblENSG00000110066 NCBI Gene51111

Locus: gene with protein productLocation: 11q13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Histone-lysine N-methyltransferase KMT5BQ4FZB7

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSUV420H1 · CGI-85

View full nomenclature history (5)

Previous symbolsSUV420H1

Alias symbolsCGI-85

Previous namessuppressor of variegation 4-20 homolog 1 (Drosophila), lysine (K)-specific methyltransferase 5B

Alias namesHistone-lysine N-methyltransferase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn

Complex neurodevelopmental disorder

Neural Tube Defects

Autism Spectrum Disorder

Poisoning

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Histone lysine methyltransferasesSET domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.