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LIF

Gene

LIF interleukin 6 family cytokine

HGNCHGNC:6596EnsemblENSG00000128342NCBI Gene3976
Locus: gene with protein productLocation: 22q12.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Leukemia inhibitory factorP15018

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCDF · DIA · HILDA
View full nomenclature history (10)
Alias symbolsCDF, DIA, HILDA
Previous namesleukemia inhibitory factor, LIF, interleukin 6 family cytokine
Alias namesdifferentiation inhibitory activity, differentiation-inducing factor, hepatocyte-stimulating factor III, cholinergic differentiation factor, human interleukin in DA cells

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dupuytren Contracture
Alcohol drinking
Glaucoma, Open-Angle
Breast Neoplasms
Glaucoma
Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Receptor ligandsInterleukin 6 type cytokine family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.