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MMP12

Gene

matrix metallopeptidase 12

HGNCHGNC:7158EnsemblENSG00000262406NCBI Gene4321
Locus: gene with protein productLocation: 11q22.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHME
View full nomenclature history (3)
Alias symbolsHME
Previous namesmatrix metalloproteinase 12 (macrophage elastase)
Alias namesmacrophage elastase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dermatitis, Atopic
Stroke
Helicobacter Infections
Ischemic Stroke
Atherosclerosis
Aneurysm
Aortic Aneurysm
Coronary Artery Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

M10 matrix metallopeptidasesElastases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.