NLRP5

Gene

NLR family pyrin domain containing 5

HGNCHGNC:21269 EnsemblENSG00000171487 NCBI Gene126206

Locus: gene with protein productLocation: 19q13.43

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNALP5 · PYPAF8 · MATER · PAN11 · CLR19.8

View full nomenclature history (8)

Previous symbolsNALP5

Alias symbolsPYPAF8, MATER, PAN11, CLR19.8

Previous namesNACHT, leucine rich repeat and PYD containing 5

Alias namesnucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5, maternal antigen that embryos require

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Toriello-Lacassie-Droste syndrome

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NLR familyPyrin domain containingSubcortical maternal complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.