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PAPPA

Gene

pappalysin 1

HGNCHGNC:8602EnsemblENSG00000182752NCBI Gene5069
Locus: gene with protein productLocation: 9q33.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPAPP-A · PAPPA1 · IGFBP-4ase · PAPA · ASBABP2 · DIPLA1
View full nomenclature history (10)
Alias symbolsPAPP-A, PAPPA1, IGFBP-4ase, PAPA, ASBABP2, DIPLA1
Previous namespregnancy-associated plasma protein A, pappalysin 1
Alias namesinsulin-like growth factor-dependent IGF binding protein-4 protease, aspecific BCL2 ARE-binding protein 2, differentially placenta 1 expressed protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Osteoarthritis, Hip
Osteoarthritis, Knee
Osteoarthritis
Lupus Erythematosus, Systemic
Brain Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PappalysinsSushi domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.