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RAPGEFL1

Gene

Rap guanine nucleotide exchange factor like 1

HGNCHGNC:17428EnsemblENSG00000108352NCBI Gene51195
Locus: gene with protein productLocation: 17q21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLink-GEFII
View full nomenclature history (4)
Alias symbolsLink-GEFII
Previous namesRAP guanine-nucleotide-exchange factor (GEF)-like 1, Rap guanine nucleotide exchange factor (GEF)-like 1
Alias namesLink guanine nucleotide exchange factor II

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Alcohol drinking
Placental abruption
Osteoarthritis, Knee
Actinic keratosis
Chronic bronchitis
Colonic Polyps
Familial prostate cancer
Prostatic Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.