S100A12

Gene

S100 calcium binding protein A12

HGNCHGNC:10489 EnsemblENSG00000163221 NCBI Gene6283

Locus: gene with protein productLocation: 1q21.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Protein S100-A12P80511

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asp6 · MRP6 · CGRP · CAAF1 · CAGC · ENRAGE

View full nomenclature history (12)

Alias symbolsp6, MRP6, CGRP, CAAF1, CAGC, ENRAGE

Previous namesS100 calcium-binding protein A12 (calgranulin C)

Alias namesextracellular newly identified RAGE-binding protein, calcium-binding protein in amniotic fluid 1, migration inhibitory factor-related protein 6, neutrophil S100 protein, calgranulin C

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Alzheimer's Disease

Parkinson's Disease

Multiple Sclerosis

Neurodegenerative Diseases

Lysosomal Storage Diseases

Periodontitis

COVID-19

Inflammatory Bowel Diseases

Arthritis, Rheumatoid

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

S100 calcium binding proteinsEF-hand domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.