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UBA3

Gene

ubiquitin like modifier activating enzyme 3

HGNCHGNC:12470EnsemblENSG00000144744NCBI Gene9039
Locus: gene with protein productLocation: 3p14.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

NEDD8-activating enzyme E1 catalytic subunitQ8TBC4

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asUBE1C · hUba3 · NAE2
View full nomenclature history (8)
Previous symbolsUBE1C
Alias symbolshUba3, NAE2
Previous namesubiquitin-activating enzyme E1C (homologous to yeast UBA3), ubiquitin-activating enzyme E1C (UBA3 homolog, yeast), ubiquitin-like modifier activating enzyme 3
Alias namesNEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 subunit 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dengue
Leukemia, Myeloid, Acute
Neurodegenerative Diseases
Cholangiocarcinoma
Carcinoma, Non-Small-Cell Lung
Alcohol drinking
Celiac Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ubiquitin like modifier activating enzymes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.