Disease Susceptibility
Recent clinical, regulatory, research and industry developments relating to this disease.
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Applying an evolutionary mismatch framework to understand disease susceptibility.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Therapeutic landscape
Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.
Approval — Treatment of influenza Tamiflu is indicated in adults and children including full term ne… (2002)
Regulatory timeline
Drug regulatory events matched to this condition by indication — EMA.
European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Disease Susceptibility17
- Gastrointestinal Microbiome9
- Immunity5
- Tumor Microenvironment4
- Biomarkers, Tumor3
- Autophagy2
- Betacoronavirus2
- Biomarkers2
Leading journals6
- Frontiers in immunology20
- International journal of molecular sciences11
- Molecular cancer10
- EBioMedicine5
- Frontiers in cellular and infection microbiology3
- Journal of immunology research3
Leading researchers8
- Wang S3
- Akdis CA2
- Brüggen MC2
- Jiang P2
- Kanneganti TD2
- Kesavardhana S2
- Kroemer G2
- Li M2
Affiliations (unnormalised)6
- School of Medicine5
- St. Jude Children's Research Hospital3
- University of California3
- Abramson Cancer Center2
- Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute.2
- Centre de Recherche des Cordeliers2
Disease biology
Key proteins & gene products studied in this disease. Number shows shared papers.
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Disease susceptibility refers to a constitutional or bodily condition that makes tissues react in special ways to certain external stimuli, increasing the likelihood of developing particular diseases. The supplied literature grounding treats it as a broad host-state concept rather than a single disease entity. Its coverage is mainly immunologic and epidemiologic, with examples spanning inflammatory, infectious, neurodegenerative, and cancer-related contexts.
The grounding does not support a single cause or aetiology for disease susceptibility. It is described as a general predisposition shaped by the body's condition and by interactions with extrinsic stimuli. The supplied abstracts also point to multifactorial influences in specific diseases, including genetics, infections, environmental factors, and tissue microenvironmental signals, but not as causes of susceptibility itself.
The grounding supports a broad mechanism in which host responses to external stimuli are altered through immune, inflammatory, and signaling pathways. Co-studied mechanisms include signal transduction, immunity, innate immunity, immunomodulation, host-pathogen interactions, gastrointestinal microbiome effects, energy metabolism, and tumor microenvironment interactions. The literature also links susceptibility-related biology to cytokine activity, immune checkpoint proteins, membrane and carrier proteins, and inflammatory mediators.
The grounding does not provide disease-specific risk factors for susceptibility as a standalone entity. In the supplied abstracts, factors associated with increased disease risk in specific conditions include age, genetic factors, head injuries, vascular disease, infections, environmental factors, and altered immune or tumor microenvironment states. These are examples from related diseases rather than validated risk factors for the general concept of disease susceptibility.
AI-generated summary grounded in MeSH and 6 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.