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Drug

Calcium

In clinical development
Actively researchedLate-stage developmentCooling momentum
Also known as Kalzium, Calcio, Ca - Calcium, Calcium, elemental+1 more

Kalzium, Calcio, Ca - Calcium, Calcium, elemental, Elemental calcium.

RxNorm1895ChEMBLCHEMBL1200496UNIISY7Q814VUP
66
Research papers
3
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium: An Ex-Vivo Study

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

Can Fluoxetine Mitigate the Mental Health Decline Seen in Patients With Musculoskeletal Trauma?

Clinical trial2026-05-14Results posted · ClinicalTrials.gov

PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery"

Clinical trial2026-03-24Results expected Q4 2028 · ClinicalTrials.gov

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications.

Research2026-03-17Advanced science (Weinheim, Baden-Wurttemberg, Germany)

EndoCompass project: research roadmap for calcium and bone endocrinology.

Research2025-10-01European journal of endocrinology

Randomized Clinical Trial of RANKL Inhibition With Denosumab on Mammographic Density in Premenopausal Women With Dense Breasts (TRIDENT)

Clinical trial2025-09-17Primary completion · ClinicalTrials.gov

Efficacy and Safety of Combination Denosumab With Eldecalcitol for Postmenopausal Women With Osteoporosis.(ESCORT)

Clinical trial2025-07-16Completed · ClinicalTrials.gov

Understanding chronic inflammation: couplings between cytokines, ROS, NO, Ca<sub>i</sub> <sup>2+</sup>, HIF-1α, Nrf2 and autophagy.

Research2025-04-08Frontiers in immunology

A Randomised, Double-blind, Parallel, Multinational Study to Compare the Efficacy, Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of MB09 (Proposed Denosumab Biosimilar) vs. Prolia® (EU-sourced) in Postmenopausal Osteoporosis

Clinical trial2025-03-21Results posted · ClinicalTrials.gov

Calcium Administration to Prevent Hypotension Caused by Diltiazem Administration in the Treatment of Atrial Fibrillation With Rapid Ventricular Response

Clinical trial2025-01-31Primary completion · ClinicalTrials.gov

The NMDAR-BK channelosomes as regulators of synaptic plasticity.

Research2025-01-28Biochemical Society transactions

Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy.

Research2024-12-25Cells

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Calcium
Aliases & brands
KalziumCalcioCa - CalciumCalcium, elementalElemental calcium
RxNorm CUI
1895
ChEMBL ID
CHEMBL1200496
UNII
SY7Q814VUP

Clinical trials

52 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
52
registered trials across all phases
LATEST COMPLETION 2025
3
Active studies
2
Recruiting
33
Late-stage (III+)
40
Completed
9
Discontinued
PHASE DISTRIBUTIONn = 52
Early Phase 11Phase 12Phase 216Phase 2 / 31Phase 312Phase 410Phase N / A10

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Efficacy and Safety of Combination Denosumab With Eldecalcitol for Postmenopausal Women With Osteoporosis.(ESCORT)

CompletedPH IVXi'an Honghui Hospitaln=1002025

Reducing Diltiazem-Related Hypotension in Atrial Fibrillation: The Role of IV Calcium Pretreatment

CompletedPH IVHaseki Training and Research Hospitaln=2172024

ZEST II for Osteoporotic Fracture Prevention

CompletedPH IVSusan L. Greenspann=3102022

Generic Zoledronic Acid Versus Original Zoledronic Acid: A Multicenter, Randomized, Open, Paralled-controlled Clinical Postmenopausal Osteoporotic Women Efficacy and Safety Research.

Unknown statusPH IVCttqn=4662020

Teriparatide and Risedronate in the Treatment of Patients With Severe Postmenopausal Osteoporosis: Comparative Effects on Vertebral Fractures

CompletedPH IVKey trialEli Lilly and Companyn=1,3662016

Recent completions

Trials that read out recently, adding to the completed evidence base.

Efficacy and Safety of Combination Denosumab With Eldecalcitol for Postmenopausal Women With Osteoporosis.(ESCORT)

CompletedPH IVXi'an Honghui Hospitaln=1002025

Can Fluoxetine Mitigate the Mental Health Decline Seen in Patients With Musculoskeletal Trauma?

CompletedPH IIUniversity of Floridan=552025

Effects of Low Dose Aspirin in Bipolar Disorder (The A-Bipolar RCT)

CompletedPH IILars Vedel Kessingn=2502024

Reducing Diltiazem-Related Hypotension in Atrial Fibrillation: The Role of IV Calcium Pretreatment

CompletedPH IVHaseki Training and Research Hospitaln=2172024

A Randomised, Double-blind, Parallel, Multinational Study to Compare the Efficacy, Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of MB09 (Proposed Denosumab Biosimilar) vs. Prolia® (EU-sourced) in Postmenopausal Osteoporosis

CompletedPH IIImAbxience Research S.L.n=5582024

An Open-label, Ascending Multiple-dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Romosozumab in Children and Adolescents With Osteogenesis Imperfecta

CompletedPH IAmgenn=252023

Research activity

66 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19962026
Most influential

Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study.

Circulation · 2007 · 2,170 cites

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.

Diabetes · 2012 · 1,684 cites

Transcriptional regulation by calcium, calcineurin, and NFAT.

Genes & development · 2003 · 1,522 cites

The role of oxidative stress in Parkinson's disease.

Journal of Parkinson's disease · 2013 · 1,292 cites

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

The Journal of clinical investigation · 2004 · 1,111 cites

Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.

The Journal of experimental medicine · 1998 · 1,050 cites
Recent papers

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026

The multifaceted role of mitochondria in autism spectrum disorder.

Molecular psychiatry · 2025 · 65 cites

Understanding chronic inflammation: couplings between cytokines, ROS, NO, Ca<sub>i</sub> <sup>2+</sup>, HIF-1α, Nrf2 and autophagy.

Frontiers in immunology · 2025 · 37 cites

Invited Mini Review Metabolic Bone Disease of Prematurity: Overview and Practice Recommendations.

Hormone research in paediatrics · 2025 · 11 cites

EndoCompass project: research roadmap for calcium and bone endocrinology.

European journal of endocrinology · 2025

The NMDAR-BK channelosomes as regulators of synaptic plasticity.

Biochemical Society transactions · 2025
Major research themes8
Calcium11Neuronal Plasticity5Neurons4Synapses4Astrocytes3Calcium Signaling3Autism Spectrum Disorder2Bone Density Conservation Agents2
Journals, researchers & institutions
Top journals
  • The Journal of neuroscience : the official journal of the Society for Neuroscience7
  • International journal of molecular sciences4
  • Nature communications4
  • Nature3
  • Aging cell2
  • Biochemical Society transactions2
Leading researchers
  • Dell'Acqua ML2
  • Greenberg ME2
  • Li Y2
  • Volterra A2
  • Adachi K1
  • Agarwal HK1
  • Amal H1
  • Amiri M1
Leading institutions
free-text, unnormalised
  • Children's Hospital3
  • School of Medicine3
  • Indiana University School of Medicine2
  • UCL Queen Square Institute of Neurology2
  • University Hospital2
  • University of Alabama at Birmingham2

Related diseases

10 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Vitamin D

Studied across 16 of the same disease areas as Calcium in the shared literature.

16 shared diseases4 shared papers
Dopamine

Studied across 12 of the same disease areas as Calcium in the shared literature.

12 shared diseases3 shared papers
Nitric Oxide

Studied across 13 of the same disease areas as Calcium in the shared literature.

13 shared diseases2 shared papers
Testosterone

Studied across 12 of the same disease areas as Calcium in the shared literature.

12 shared diseases1 shared paper
Triglycerides

Studied across 11 of the same disease areas as Calcium in the shared literature.

11 shared diseases1 shared paper
Parathyroid Hormone

Studied across 5 of the same disease areas as Calcium in the shared literature.

5 shared diseases2 shared papers
Cholecalciferol

Studied across 6 of the same disease areas as Calcium in the shared literature.

6 shared diseases1 shared paper
Luteinizing Hormone

Studied across 6 of the same disease areas as Calcium in the shared literature.

6 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials