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Drug

Lactic Acid

In clinical development
Actively researchedLate-stage developmentRising momentum
Also known as 2-Hydroxypropanoic acid, 2-Hydroxypropionic acid, 4XLA Activator, Acidum lacticum+31 more

2-Hydroxypropanoic acid, 2-Hydroxypropionic acid, 4XLA Activator, Acidum lacticum, Amlactin, Astri-UC, Atrac-Tain, Dermaplex, Geri-Hydrolac, Ionosol-MB, LACTIC ACID, UNSPECIFIED FORM, Lac-Hydrin, Laclotion, Lacticare, Lacticum acidum, Lactinol, Milchsäure, Milk acid, Oxy Gard, Penederm, Phexx, Phexxi, Pur-Oxy, SLT, U-Lactin, Valiant Barrier, Valiant Shield, ácido láctico, Lactic Acid 10%, Dianeal Low Calcium 1.5, Dianeal Low Calcium 2.5, Dianeal Low Calcium 4.25, Dianeal PD-2/1.5, Dianeal PD-2/2.5, Dianeal PD-2/4.25.

34
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Role of Histone Lactylation in Neurological Disorders.

Research2025-08-18International journal of molecular sciences

Lactate and lactylation in cancer.

Research2025-02-12Signal transduction and targeted therapy

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Lactic Acid
Aliases & brands
2-Hydroxypropanoic acid2-Hydroxypropionic acid4XLA ActivatorAcidum lacticumAmlactinAstri-UCAtrac-TainDermaplexGeri-HydrolacIonosol-MBLACTIC ACID, UNSPECIFIED FORMLac-HydrinLaclotionLacticareLacticum acidumLactinolMilchsäureMilk acidOxy GardPenedermPhexxPhexxiPur-OxySLTU-LactinValiant BarrierValiant Shieldácido lácticoLactic Acid 10%Dianeal Low Calcium 1.5Dianeal Low Calcium 2.5Dianeal Low Calcium 4.25Dianeal PD-2/1.5Dianeal PD-2/2.5Dianeal PD-2/4.25
RxNorm CUI
28393
ChEMBL ID
CHEMBL1200559
ATC codes
G01AD01
UNII
33X04XA5AT

Clinical trials

44 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
44
registered trials across all phases
LATEST COMPLETION 2024
1
Active studies
1
Recruiting
42
Late-stage (III+)
42
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 44
Phase 11Phase 21Phase 336Phase 45Phase N / A1

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

34 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20072025
Most influential

Lactate metabolism in human health and disease.

Signal transduction and targeted therapy · 2022 · 928 cites

Targeting lactate metabolism for cancer therapeutics.

The Journal of clinical investigation · 2013 · 853 cites

Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020 · 688 cites
Recent papers
Major research themes8
Lactic Acid13Neoplasms5Glycolysis4Astrocytes3Cognition3Histones3Monocarboxylic Acid Transporters3Alzheimer Disease2
Journals, researchers & institutions
Top journals
  • International journal of molecular sciences4
  • Nature communications3
  • Frontiers in immunology2
  • Signal transduction and targeted therapy2
  • Autophagy1
  • Blood1
Leading researchers
  • Wang X3
  • Alhazzani W2
  • Chen L2
  • Magistretti PJ2
  • Pellerin L2
  • Wang W2
  • Wang Z2
  • Wu X2
Leading institutions
free-text, unnormalised
  • McMaster University2
  • Advocate Children's Hospital1
  • All India Institute of Medical Sciences1
  • Apollo Hospitals1
  • ASAN Medical Center1
  • Australian and New Zealand Intensive Care Research Centre1

Related diseases

6 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

4 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 6 of the same disease areas as Lactic Acid in the shared literature.

6 shared diseases2 shared papers

Studied across 6 of the same disease areas as Lactic Acid in the shared literature.

6 shared diseases1 shared paper

Studied across 3 of the same disease areas as Lactic Acid in the shared literature.

3 shared diseases1 shared paper

Studied across 2 of the same disease areas as Lactic Acid in the shared literature.

2 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials